In 2001, Clooney's fame widened with the release of his biggest commercial success, the heist comedy remake Ocean's Eleven, the first of what became a trilogy starring Clooney.
He made his directorial debut a year later with the biographical spy comedy Confessions of a Dangerous Mind, and has since directed the historical drama Good Night, and Good Luck (2005), the sports comedy Leatherheads (2008), the political drama The Ides of March (2011), and the war film The Monuments Men (2014).
Clooney began appearing in films while working on ER.
His first major Hollywood role was in the horror comedy-crime thriller From Dusk till Dawn, directed by Robert Rodriguez and co-starring Harvey Keitel.
Clooney's first major role came in 1984 in the short-lived sitcom E/R (not to be confused with ER, the better-known hospital drama, on which Clooney also co-starred a decade later).
He played a handyman on the series The Facts of Life and appeared as Bobby Hopkins, a detective, on an episode of The Golden Girls.
His first prominent role was a semi-regular supporting role in the sitcom Roseanne, playing Roseanne Barr's supervisor Booker Brooks, followed by the role of a construction worker on Baby Talk, a co-starring role on the CBS drama Bodies of Evidence as Detective Ryan Walker, and then a year-long turn as Det. In 1988, Clooney played a role in the comedy-horror film Return of the Killer Tomatoes. Doug Ross, alongside Anthony Edwards, Julianna Margulies, and Noah Wyle, on the hit NBC medical drama ER from 1994 to 1999.
After leaving the series in 1999, he made a cameo appearance in the 6th season and returned for a guest spot in the show's final season.
His humanitarian work includes his advocacy of finding a resolution for the Darfur conflict, raising funds for the 2010 Haiti earthquake, Armenian Genocide recognition, 2004 tsunami, and 9/11 victims, and creating documentaries such as Sand and Sorrow to raise awareness about international crises.
George Clooney looks dapper in all black while heading to dinner on Saturday evening (May 25) in London, England.
Mark Wahlberg may have been right when he claimed these two were no longer together.
Clooney's first role was as an extra in the television mini-series Centennial in 1978, which was based on the novel of the same name by James A.
Michener and was partly filmed in Clooney's hometown of Augusta, Kentucky.
George Clooney and his love of two years, Stacy Keibler, have ended their relationship!